- 1.
Moris, D. et al. The role of reactive oxygen species in myocardial redox signaling and regulation. Ann. Transl. Med. 5, 324 (2017).
PubMed PubMed Central Article CAS Google Scholar
- 2.
Zhou, T., Chuang, C. C. & Zuo, L. Molecular characterization of reactive oxygen species in myocardial ischemia-reperfusion injury. Biomed. Res. Int. 2015, 864946 (2015).
PubMed PubMed Central Google Scholar
- 3.
Winyard, P. G., Moody, C. J. & Jacob, C. Oxidative activation of antioxidant defence. Trends Biochem. Sci. 30, 453–461 (2005).
CAS PubMed Article Google Scholar
- 4.
Zhou, Y.-Q. et al. Reactive oxygen species scavengers ameliorate mechanical allodynia in a rat model of cancer-induced bone pain. Redox. Biol. 14, 391–397 (2018).
CAS PubMed Article PubMed Central Google Scholar
- 5.
Meeus, M., Nijs, J., Hermans, L., Goubert, D. & Calders, P. The role of mitochondrial dysfunctions due to oxidative and nitrosative stress in the chronic pain or chronic fatigue syndromes and fibromyalgia patients: peripheral and central mechanisms as therapeutic targets?. Expert Opin. Ther. Targets 17, 1081–1089 (2013).
CAS PubMed Article Google Scholar
- 6.
Baykal, T., Seferoglu, B., Karsan, O., Kiziltunc, A. & Senel, K. Antioxidant profile in patients with complex regional pain syndrome type I. Int. J. Rheum. Dis. 17, 156–158 (2014).
CAS PubMed Article PubMed Central Google Scholar
- 7.
Stevens, J. L., Feelisch, M. & Martin, D. S. Perioperative oxidative stress: The unseen enemy. Anesth. Analg. 129, 1749–1760 (2019).
CAS PubMed Article Google Scholar
- 8.
Banfi, G., Iorio, E. L. & Corsi, M. M. Oxidative stress, free radicals and bone remodeling. Clin. Chem. Lab. Med. 46, 1550–1555 (2008).
CAS PubMed PubMed Central Google Scholar
- 9.
Sandukji, A., Al-Sawaf, H., Mohamadin, A., Alrashidi, Y. & Sheweita, S. Oxidative stress and bone markers in plasma of patients with long-bone fixative surgery: role of antioxidants. Hum. Exp. Toxicol. 30, 435–442 (2011).
CAS PubMed Article Google Scholar
- 10.
Pansarasa, O. et al. Age and sex differences in human skeletal muscle: role of reactive oxygen species. Free Radic. Res. 33, 287–293 (2000).
CAS PubMed Article Google Scholar
- 11.
Lewis, L. N. et al. Lower dietary and circulating vitamin C in middle- and older-aged men and women are associated with lower estimated skeletal muscle mass. J. Nutr. 150, 2789–2798 (2020).
PubMed PubMed Central Article Google Scholar
- 12.
Aghajanian, P., Hall, S., Wongworawat, M. D. & Mohan, S. The roles and mechanisms of actions of vitamin C in bone: new developments. J. Bone Miner. Res. 30, 1945–1955 (2015).
CAS PubMed PubMed Central Article Google Scholar
- 13.
Sorice, A. et al. Ascorbic acid: its role in immune system and chronic inflammation diseases. Mini. Rev. Med. Chem. 14, 444–452 (2014).
CAS PubMed Article Google Scholar
- 14.
Sugimoto, M. et al. Impaired expression of noncollagenous bone matrix protein mRNAs during fracture healing in ascorbic acid-deficient rats. J. Bone Miner. Res. 13, 271–278 (1998).
CAS PubMed Article Google Scholar
- 15.
Zhang, Z. M., Jiang, L. S., Jiang, S. D. & Dai, L. Y. Osteogenic potential and responsiveness to leptin of mesenchymal stem cells between postmenopausal women with osteoarthritis and osteoporosis. J. Orthop. Res. 27, 1067–1073 (2009).
CAS PubMed Article Google Scholar
- 16.
Alcantara-Martos, T., Delgado-Martinez, A. D., Vega, M. V., Carrascal, M. T. & Munuera-Martinez, L. Effect of vitamin C on fracture healing in elderly osteogenic disorder shionogi rats. J. Bone Joint Surg. Br. 89, 402–407 (2007).
CAS PubMed Article Google Scholar
- 17.
Sahni, S. et al. High vitamin C intake is associated with lower 4-year bone loss in elderly men. J. Nutr. 138, 1931–1938 (2008).
CAS PubMed PubMed Central Article Google Scholar
- 18.
Leveille, S. G. et al. Dietary vitamin C and bone mineral density in postmenopausal women in Washington State, USA. J. Epidemiol. Commun. Health 51, 479–485 (1997).
CAS Article Google Scholar
- 19.
Hall, S. L. & Greendale, G. A. The relation of dietary vitamin C intake to bone mineral density: results from the PEPI study. Calcif. Tissue Int. 63, 183–189 (1998).
CAS PubMed Article Google Scholar
- 20.
Brzezińska, O., Łukasik, Z., Makowska, J. & Walczak, K. Role of vitamin C in osteoporosis development and treatment-a literature review. Nutrients 12, 2394 (2020).
PubMed Central Article CAS PubMed Google Scholar
- 21.
Aïm, F., Klouche, S., Frison, A., Bauer, T. & Hardy, P. Efficacy of vitamin C in preventing complex regional pain syndrome after wrist fracture: A systematic review and meta-analysis. Orthop. Traumatol. Surg. Res. 103, 465–470 (2017).
PubMed Article Google Scholar
- 22.
Chen, S., Roffey, D. M., Dion, C. A., Arab, A. & Wai, E. K. Effect of perioperative vitamin C supplementation on postoperative pain and the incidence of chronic regional pain syndrome: a systematic review and meta-analysis. Clin. J. Pain. 32, 179–185 (2016).
PubMed Article Google Scholar
- 23.
Evaniew, N., McCarthy, C., Kleinlugtenbelt, Y. V., Ghert, M. & Bhandari, M. Vitamin C to prevent complex regional pain syndrome in patients with distal radius fractures: A meta-analysis of randomized controlled trials. J. Orthop. Trauma 29, e235-241 (2015).
PubMed Article Google Scholar
- 24.
Meena, S., Sharma, P., Gangary, S. K. & Chowdhury, B. Role of vitamin C in prevention of complex regional pain syndrome after distal radius fractures: a meta-analysis. Eur. J. Orthop. Surg. Traumatol. 25, 637–641 (2015).
PubMed Article Google Scholar
- 25.
Shibuya, N., Humphers, J. M., Agarwal, M. R. & Jupiter, D. C. Efficacy and safety of high-dose vitamin C on complex regional pain syndrome in extremity trauma and surgery–systematic review and meta-analysis. J. Foot Ankle Surg. 52, 62–66 (2013).
PubMed Article Google Scholar
- 26.
Moher, D., Liberati, A., Tetzlaff, J. & Altman, D. G. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ 339, b2535 (2009).
PubMed PubMed Central Article Google Scholar
- 27.
Higgins, J. P. et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ 343, d5928 (2011).
PubMed PubMed Central Article Google Scholar
- 28.
Behrend, H. et al. Vitamin C demand is increased after total knee arthroplasty: a double-blind placebo-controlled-randomized study. Knee Surg. Sports Traumatol. Arthrosc. 27, 1182–1188 (2019).
PubMed Article Google Scholar
- 29.
Ekrol, I., Duckworth, A. D., Ralston, S. H., Court-Brown, C. M. & McQueen, M. M. The influence of vitamin C on the outcome of distal radial fractures: a double-blind, randomized controlled trial. J Bone Joint Surg Am 96, 1451–1459 (2014).
PubMed Article Google Scholar
- 30.
Jain, S. K., Dar, M. Y., Kumar, S., Yadav, A. & Kearns, S. R. Role of anti-oxidant (vitamin-C) in post-operative pain relief in foot and ankle trauma surgery: A prospective randomized trial. Foot Ankle Surg. 25, 542–545 (2019).
PubMed Article Google Scholar
- 31.
Lee, G. W., Yang, H. S., Yeom, J. S. & Ahn, M. W. The efficacy of vitamin C on postoperative outcomes after posterior lumbar interbody fusion: A randomized, placebo-controlled trial. Clin. Orthop. Surg. 9, 317–324 (2017).
PubMed PubMed Central Article Google Scholar
- 32.
Zollinger, P. E., Tuinebreijer, W. E., Breederveld, R. S. & Kreis, R. W. Can vitamin C prevent complex regional pain syndrome in patients with wrist fractures? A randomized, controlled, multicenter dose-response study. J. Bone Joint Surg. Am. 89, 1424–1431 (2007).
CAS PubMed Article Google Scholar
- 33.
Zollinger, P. E., Tuinebreijer, W. E., Kreis, R. W. & Breederveld, R. S. Effect of vitamin C on frequency of reflex sympathetic dystrophy in wrist fractures: a randomised trial. Lancet 354, 2025–2028 (1999).
CAS PubMed Article PubMed Central Google Scholar
- 34.
Jacques, H. et al. Prospective randomized study of the vitamin C effect on pain and complex pain regional syndrome after total knee arthroplasty. Int Orthop. 2021 Feb 22. https://doi.org/10.1007/s00264-021-04981-y. Online ahead of print.
- 35.
Malmir, H., Shab-Bidar, S. F& Djafarian, K. Vitamin C intake in relation to bone mineral density and risk of hip fracture and osteoporosis: a systematic review and meta-analysis of observational studies. Br. J. Nutr. 119, 847–858 (2018).
- 36.
Cesari, M. et al. Antioxidants and physical performance in elderly persons: the Invecchiare in Chianti (InCHIANTI) study. Am. J. Clin. Nutr. 79, 289–294 (2004).
CAS PubMed Article Google Scholar
- 37.
Saito, K. et al. A significant relationship between plasma vitamin C concentration and physical performance among Japanese elderly women. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences 67, 295–301 (2012).
Article CAS Google Scholar
- 38.
Dickinson, W. H., Duwelius, P. J. & Colville, M. R. Muscle strength testing following surgery for acetabular fractures. J. Orthop. Trauma 7, 39–46 (1993).
CAS PubMed Article Google Scholar
- 39.
Borrelli, J. Jr., Ricci, W. M., Anglen, J. O., Gregush, R. & Engsberg, J. Muscle strength recovery and its effects on outcome after open reduction and internal fixation of acetabular fractures. J. Orthop. Trauma 20, 388–395 (2006).
PubMed Article PubMed Central Google Scholar
- 40.
Borrelli, J. Jr., Goldfarb, C., Ricci, W., Wagner, J. M. & Engsberg, J. R. Functional outcome after isolated acetabular fractures. J. Orthop. Trauma 16, 73–81 (2002).
PubMed Article Google Scholar
- 41.
Veldman, P. H., Reynen, H. M., Arntz, I. E. & Goris, R. J. Signs and symptoms of reflex sympathetic dystrophy: prospective study of 829 patients. Lancet 342, 1012–1016 (1993).
CAS PubMed Article Google Scholar
- 42.
Besse, J. L., Gadeyne, S., Galand-Desmé, S., Lerat, J. L. & Moyen, B. Effect of vitamin C on prevention of complex regional pain syndrome type I in foot and ankle surgery. Foot Ankle Surg 15, 179–182 (2009).
PubMed Article Google Scholar
- 43.
Guo, T.-Z., Wei, T., Huang, T.-T., Kingery, W. S. & Clark, J. D. Oxidative stress contributes to fracture/cast-induced inflammation and pain in a rat model of complex regional pain syndrome. J. Pain 19, 1147–1156 (2018).
CAS PubMed PubMed Central Article Google Scholar
- 44.
Zollinger, P. E. et al. No higher risk of CRPS after external fixation of distal radial fractures-subgroup analysis under randomised vitamin C prophylaxis. Open Orthop. J. 4, 71–75 (2010).
PubMed PubMed Central Google Scholar
- 45.
Cazeneuve, J. F., Leborgne, J. M., Kermad, K. & Hassan, Y. Vitamin C and prevention of reflex sympathetic dystrophy following surgical management of distal radius fractures. Acta Orthop. Belg 68, 481–484 (2002).
CAS PubMed Google Scholar
- 46.
Erez, A., Bloom, M. C. & Wells, M. T. Using random rather than fixed effects models in meta-analysis: Implications for situational specificity and validity generalization. Pers. Psychol. 49, 275–306 (1996).
Article Google Scholar
- 47.
Giladi, A. M., Dossett, L. A., Fleming, S. B., Abumrad, N. N. & Cotton, B. A. High-dose antioxidant administration is associated with a reduction in post-injury complications in critically ill trauma patients. Injury 42, 78–82 (2011).
PubMed Article Google Scholar
- 48.
Hill, A. et al. Effects of vitamin C on organ function in cardiac surgery patients: A systematic review and meta-analysis. Nutrients 11, 2103 (2019).
CAS PubMed Central Article PubMed Google Scholar
- 49.
Padayatty, S. J. et al. Vitamin C pharmacokinetics: implications for oral and intravenous use. Ann. Intern Med. 140, 533–537 (2004).
CAS PubMed Article Google Scholar
- 50.
Rewhorn, M. J., Leung, A. H., Gillespie, A., Moir, J. S. & Miller, R. Incidence of complex regional pain syndrome after foot and ankle surgery. J. Foot Ankle Surg. 53, 256–258 (2014).
PubMed Article Google Scholar
- 51.
Bean, D. J., Johnson, M. H. & Kydd, R. R. The outcome of complex regional pain syndrome type 1: a systematic review. J. Pain 15, 677–690 (2014).
PubMed Article Google Scholar